Drug interactions
Netupitant-palonosetron + Olaparib
Severity: Major
Netupitant-palonosetron and Olaparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant may increase olaparib exposure via CYP3A inhibition, raising the risk of anemia, nausea and other adverse effects.
What this interaction means in plain words
Netupitant-palonosetron and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Olaparib belongs to Oncology.
Why it happens
Netupitant inhibits CYP3A4, reducing olaparib metabolism.
What to do
Avoid if possible. If unavoidable, reduce the olaparib dose per labeling and monitor blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Netupitant-palonosetron with Olaparib?
MediHelp rates the interaction as major. Netupitant-palonosetron and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Netupitant may increase olaparib exposure via CYP3A inhibition, raising the risk of anemia, nausea and other adverse effects.
How serious is the interaction between Netupitant-palonosetron and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the olaparib dose per labeling and monitor blood counts.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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