Drug interactions
Netupitant / palonosetron + Phenelzine
Severity: Moderate
Netupitant / palonosetron and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
5-HT3 antagonists have been associated with serotonin syndrome when combined with serotonergic drugs. MAOIs add to this risk, although the evidence for palonosetron is limited.
What this interaction means in plain words
Netupitant / palonosetron and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; netupitant also inhibits CYP3A4, though this is not a major factor with phenelzine.
What to do
If the combination is necessary, monitor for agitation, tremor, hyperthermia, and clonus. Stop and treat if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Phenelzine?
MediHelp rates the interaction as moderate. Netupitant / palonosetron and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. 5-HT3 antagonists have been associated with serotonin syndrome when combined with serotonergic drugs. MAOIs add to this risk, although the evidence for palonosetron is limited.
How serious is the interaction between Netupitant / palonosetron and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is necessary, monitor for agitation, tremor, hyperthermia, and clonus. Stop and treat if serotonin syndrome develops.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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