Drug interactions
Netupitant / palonosetron + Rasagiline
Severity: Moderate
Netupitant / palonosetron and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palonosetron, a 5-HT3 antagonist, has been associated with serotonin syndrome when given with serotonergic drugs, and MAO inhibitors raise serotonin levels. The risk is probably low but the consequences can be serious.
What this interaction means in plain words
Netupitant / palonosetron and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effect; the causal mechanism of 5-HT3 antagonists in serotonin syndrome is not firmly established.
What to do
Monitor for mental status changes, autonomic instability and neuromuscular signs when the antiemetic is given with rasagiline. Stop the antiemetic and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Rasagiline?
MediHelp rates the interaction as moderate. Netupitant / palonosetron and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palonosetron, a 5-HT3 antagonist, has been associated with serotonin syndrome when given with serotonergic drugs, and MAO inhibitors raise serotonin levels. The risk is probably low but the consequences can be serious.
How serious is the interaction between Netupitant / palonosetron and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status changes, autonomic instability and neuromuscular signs when the antiemetic is given with rasagiline. Stop the antiemetic and treat if serotonin syndrome is suspected.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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