Drug interactions
Netupitant-palonosetron + Selegiline transdermal
Severity: Moderate
Netupitant-palonosetron and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palonosetron has been rarely linked to serotonin syndrome with serotonergic drugs. Transdermal selegiline is an MAO inhibitor at antidepressant doses, which may increase the potential for serotonergic toxicity.
What this interaction means in plain words
Netupitant-palonosetron and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects with MAO inhibition; the role of 5-HT3 antagonism is not well established.
What to do
Monitor for serotonin syndrome signs after administering the antiemetic. Stop serotonergic drugs and give supportive care if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Frequently asked questions
Can I take Netupitant-palonosetron with Selegiline transdermal?
MediHelp rates the interaction as moderate. Netupitant-palonosetron and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palonosetron has been rarely linked to serotonin syndrome with serotonergic drugs. Transdermal selegiline is an MAO inhibitor at antidepressant doses, which may increase the potential for serotonergic toxicity.
How serious is the interaction between Netupitant-palonosetron and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome signs after administering the antiemetic. Stop serotonergic drugs and give supportive care if symptoms develop.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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