Drug interactions
Netupitant / palonosetron + Selegiline
Severity: Minor
Netupitant / palonosetron and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palonosetron, a 5-HT3 antagonist, has been associated with serotonin syndrome reports, mainly with other serotonergic drugs. The risk with selegiline is theoretical. Netupitant also inhibits CYP3A4, which has little relevance to selegiline.
What this interaction means in plain words
Netupitant / palonosetron and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive serotonergic effect; not well established.
What to do
Monitor for signs of serotonin syndrome such as agitation, tremor and hyperthermia after administration. Treat the symptoms and stop the serotonergic agents if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Selegiline?
MediHelp rates the interaction as minor. Netupitant / palonosetron and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palonosetron, a 5-HT3 antagonist, has been associated with serotonin syndrome reports, mainly with other serotonergic drugs. The risk with selegiline is theoretical. Netupitant also inhibits CYP3A4, which has little relevance to selegiline.
How serious is the interaction between Netupitant / palonosetron and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome such as agitation, tremor and hyperthermia after administration. Treat the symptoms and stop the serotonergic agents if they occur.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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