Drug interactions
Nifedipine + Nitroglycerin rectal
Severity: Moderate
Nifedipine and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure through vasodilation, and together they can cause additive hypotension and orthostatic symptoms. Reflex tachycardia, dizziness and syncope may occur, especially in older patients.
What this interaction means in plain words
Nifedipine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through calcium channel blockade and nitric oxide-mediated smooth muscle relaxation.
What to do
Monitor blood pressure and orthostatic symptoms, particularly when starting or increasing either drug. Counsel patients to rise slowly and reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Nifedipine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure through vasodilation, and together they can cause additive hypotension and orthostatic symptoms. Reflex tachycardia, dizziness and syncope may occur, especially in older patients.
How serious is the interaction between Nifedipine and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly when starting or increasing either drug. Counsel patients to rise slowly and reduce doses if symptomatic hypotension occurs.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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