Drug interactions
Nifedipine + Paclitaxel protein bound
Severity: Minor
Nifedipine and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak CYP3A4 substrate and P-gp modulator, and any effect on paclitaxel exposure is uncertain and probably small. A clinically important change in paclitaxel toxicity or efficacy has not been well established.
What this interaction means in plain words
Nifedipine and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for CYP3A4 and P-glycoprotein, though the net effect is not clearly established.
What to do
No routine adjustment is needed; monitor for neutropenia and neuropathy as usual during paclitaxel therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Nifedipine and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a weak CYP3A4 substrate and P-gp modulator, and any effect on paclitaxel exposure is uncertain and probably small. A clinically important change in paclitaxel toxicity or efficacy has not been well established.
How serious is the interaction between Nifedipine and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for neutropenia and neuropathy as usual during paclitaxel therapy.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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