Drug interactions
Nifedipine + Rapacuronium
Severity: Moderate
Nifedipine and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can enhance neuromuscular blockade by non-depolarizing agents. Nifedipine may prolong or deepen the block produced by rapacuronium.
What this interaction means in plain words
Nifedipine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, potentiating non-depolarizing neuromuscular block.
What to do
Monitor neuromuscular function with a nerve stimulator and titrate the muscle relaxant dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Rapacuronium?
MediHelp rates the interaction as moderate. Nifedipine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers can enhance neuromuscular blockade by non-depolarizing agents. Nifedipine may prolong or deepen the block produced by rapacuronium.
How serious is the interaction between Nifedipine and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and titrate the muscle relaxant dose accordingly.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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