Drug interactions
Nifedipine + Xipamide
Severity: Minor
Nifedipine and Xipamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, and together with nifedipine the blood pressure lowering effects add up. This is often used intentionally, but it can cause excessive hypotension, especially with volume depletion.
What this interaction means in plain words
Nifedipine and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effect from diuresis-related volume reduction and vasodilation.
What to do
Monitor blood pressure and electrolytes, and adjust doses if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Xipamide?
MediHelp rates the interaction as minor. Nifedipine and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Xipamide is a thiazide-like diuretic, and together with nifedipine the blood pressure lowering effects add up. This is often used intentionally, but it can cause excessive hypotension, especially with volume depletion.
How serious is the interaction between Nifedipine and Xipamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and electrolytes, and adjust doses if symptomatic hypotension develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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