Drug interactions
Nilotinib + Ofatumumab sc
Severity: Moderate
Nilotinib and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can reduce immune function, so combined use may raise the risk of infection. Nilotinib is myelosuppressive and ofatumumab depletes B cells.
What this interaction means in plain words
Nilotinib and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through myelosuppression and B-cell depletion.
What to do
Monitor for signs of infection and check blood counts regularly. Screen for hepatitis B and other relevant infections before ofatumumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Ofatumumab sc?
MediHelp rates the interaction as moderate. Nilotinib and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can reduce immune function, so combined use may raise the risk of infection. Nilotinib is myelosuppressive and ofatumumab depletes B cells.
How serious is the interaction between Nilotinib and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts regularly. Screen for hepatitis B and other relevant infections before ofatumumab.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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