Drug interactions
Nilotinib + Olodaterol inhaled
Severity: Moderate
Nilotinib and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib prolongs the QT interval and beta2-agonists such as olodaterol can add cardiac effects including tachycardia, hypokalemia and QT changes. Systemic exposure from inhalation is low, but the arrhythmia risk may rise in susceptible patients.
What this interaction means in plain words
Nilotinib and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation and beta2-mediated cardiovascular effects.
What to do
Monitor ECG and potassium, correcting hypokalemia. Use the lowest effective olodaterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Nilotinib and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib prolongs the QT interval and beta2-agonists such as olodaterol can add cardiac effects including tachycardia, hypokalemia and QT changes. Systemic exposure from inhalation is low, but the arrhythmia risk may rise in susceptible patients.
How serious is the interaction between Nilotinib and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium, correcting hypokalemia. Use the lowest effective olodaterol dose.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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