Drug interactions
Nilotinib + Parecoxib
Severity: Minor
Nilotinib and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a weak-to-moderate CYP3A4 inhibitor, and parecoxib's active metabolite valdecoxib is partly cleared by CYP3A4 and CYP2C9. Exposure to valdecoxib may rise slightly, but the clinical impact is expected to be small.
What this interaction means in plain words
Nilotinib and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nilotinib inhibition of CYP3A4 may modestly reduce valdecoxib metabolism.
What to do
No routine dose change is needed; monitor for NSAID-related adverse effects such as fluid retention, hypertension or GI upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Parecoxib?
MediHelp rates the interaction as minor. Nilotinib and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib is a weak-to-moderate CYP3A4 inhibitor, and parecoxib's active metabolite valdecoxib is partly cleared by CYP3A4 and CYP2C9. Exposure to valdecoxib may rise slightly, but the clinical impact is expected to be small.
How serious is the interaction between Nilotinib and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for NSAID-related adverse effects such as fluid retention, hypertension or GI upset.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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