Drug interactions
Nilotinib + Procainamide
Severity: Contraindicated
Nilotinib and Procainamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and together they raise the risk of torsades de pointes and sudden cardiac death. Procainamide can also widen the QRS complex.
What this interaction means in plain words
Nilotinib and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation through effects on cardiac ion channels.
What to do
Avoid the combination and use a non-QT-prolonging antiarrhythmic. If unavoidable, maintain normal electrolytes and monitor ECG frequently.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Procainamide?
MediHelp rates the interaction as contraindicated. Nilotinib and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and together they raise the risk of torsades de pointes and sudden cardiac death. Procainamide can also widen the QRS complex.
How serious is the interaction between Nilotinib and Procainamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antiarrhythmic. If unavoidable, maintain normal electrolytes and monitor ECG frequently.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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