Drug interactions
Nilotinib + Propranolol
Severity: Moderate
Nilotinib and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may inhibit CYP2D6 and could raise propranolol levels, leading to bradycardia or hypotension. Nilotinib also prolongs the QT interval, and propranolol-related bradycardia can add to arrhythmic risk.
What this interaction means in plain words
Nilotinib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Propranolol belongs to Cardiovascular.
Why it happens
Nilotinib inhibits CYP2D6, which partly metabolizes propranolol, and bradycardia may add to QT-related risk.
What to do
Monitor heart rate, blood pressure and ECG during co-therapy. Reduce the propranolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Propranolol?
MediHelp rates the interaction as moderate. Nilotinib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib may inhibit CYP2D6 and could raise propranolol levels, leading to bradycardia or hypotension. Nilotinib also prolongs the QT interval, and propranolol-related bradycardia can add to arrhythmic risk.
How serious is the interaction between Nilotinib and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during co-therapy. Reduce the propranolol dose if bradycardia or hypotension develops.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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