Drug interactions
Nilotinib + Quinupristin / dalfopristin
Severity: Major
Nilotinib and Quinupristin / dalfopristin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise nilotinib concentrations. This increases the risk of QT prolongation and other dose-related toxicity.
What this interaction means in plain words
Nilotinib and Quinupristin / dalfopristin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 metabolism of nilotinib.
What to do
Use an alternative antibiotic where possible. If unavoidable, monitor ECG and electrolytes, and consider interrupting nilotinib during the antibiotic course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Quinupristin / dalfopristin?
MediHelp rates the interaction as major. Nilotinib and Quinupristin / dalfopristin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinupristin/dalfopristin inhibits CYP3A4 and may raise nilotinib concentrations. This increases the risk of QT prolongation and other dose-related toxicity.
How serious is the interaction between Nilotinib and Quinupristin / dalfopristin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where possible. If unavoidable, monitor ECG and electrolytes, and consider interrupting nilotinib during the antibiotic course.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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