Drug interactions
Nilotinib + Rabeprazole
Severity: Moderate
Nilotinib and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib capsules dissolve poorly at higher pH, so rabeprazole may reduce its absorption. Reduced nilotinib exposure may compromise leukemia control.
What this interaction means in plain words
Nilotinib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces the solubility and absorption of nilotinib.
What to do
Avoid long-acting acid suppression where possible. If needed, use an H2 blocker taken 10 hours before and 2 hours after nilotinib, or an antacid separated by about 2 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Rabeprazole?
MediHelp rates the interaction as moderate. Nilotinib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib capsules dissolve poorly at higher pH, so rabeprazole may reduce its absorption. Reduced nilotinib exposure may compromise leukemia control.
How serious is the interaction between Nilotinib and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-acting acid suppression where possible. If needed, use an H2 blocker taken 10 hours before and 2 hours after nilotinib, or an antacid separated by about 2 hours.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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