Drug interactions
Nilotinib + Sulfamethoxazole
Severity: Moderate
Nilotinib and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so the combination may add to arrhythmia risk. The risk is greater with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Nilotinib and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor QTc, or select a non-QT-prolonging antibiotic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Nilotinib and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so the combination may add to arrhythmia risk. The risk is greater with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Nilotinib and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor QTc, or select a non-QT-prolonging antibiotic when feasible.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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