Drug interactions
Nilotinib + Topiramate
Severity: Minor
Nilotinib and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is mainly cleared by CYP3A4, so induction may lower its levels and reduce efficacy. Topiramate is a weak inducer, so the effect is likely modest.
What this interaction means in plain words
Nilotinib and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nilotinib belongs to Oncology; Topiramate belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by topiramate may increase nilotinib clearance.
What to do
Monitor molecular response and nilotinib trough levels where available, and consider an alternative to strong inducers if anticonvulsant therapy is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Topiramate?
MediHelp rates the interaction as minor. Nilotinib and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib is mainly cleared by CYP3A4, so induction may lower its levels and reduce efficacy. Topiramate is a weak inducer, so the effect is likely modest.
How serious is the interaction between Nilotinib and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor molecular response and nilotinib trough levels where available, and consider an alternative to strong inducers if anticonvulsant therapy is needed.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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