Drug interactions
Nilotinib + Triamcinolone acetonide injectable
Severity: Moderate
Nilotinib and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may raise systemic triamcinolone levels after injection. This can cause corticosteroid excess, including Cushingoid features and adrenal suppression, mainly with repeated or depot dosing.
What this interaction means in plain words
Nilotinib and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by nilotinib reduces triamcinolone clearance.
What to do
Use the lowest effective triamcinolone dose and avoid repeated injections where feasible. Monitor for signs of corticosteroid excess, glucose elevation and adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Nilotinib and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may raise systemic triamcinolone levels after injection. This can cause corticosteroid excess, including Cushingoid features and adrenal suppression, mainly with repeated or depot dosing.
How serious is the interaction between Nilotinib and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triamcinolone dose and avoid repeated injections where feasible. Monitor for signs of corticosteroid excess, glucose elevation and adrenal suppression.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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