Drug interactions
Nilotinib + Triazolam
Severity: Moderate
Nilotinib and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4, which is the main route of triazolam metabolism, so triazolam levels may rise. This can cause deeper or longer sedation and psychomotor impairment.
What this interaction means in plain words
Nilotinib and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by nilotinib decreases triazolam clearance.
What to do
Start with a reduced triazolam dose and monitor for excessive sedation. Consider a benzodiazepine that is not CYP3A4-dependent, such as lorazepam or temazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Triazolam?
MediHelp rates the interaction as moderate. Nilotinib and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4, which is the main route of triazolam metabolism, so triazolam levels may rise. This can cause deeper or longer sedation and psychomotor impairment.
How serious is the interaction between Nilotinib and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a reduced triazolam dose and monitor for excessive sedation. Consider a benzodiazepine that is not CYP3A4-dependent, such as lorazepam or temazepam.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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