Drug interactions
Nilotinib + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Nilotinib and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib prolongs QTc, and vilanterol, a beta-agonist, may add cardiovascular effects. Systemic exposure from inhalation is low, so the risk is modest.
What this interaction means in plain words
Nilotinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT effects of the beta-agonist with nilotinib.
What to do
Monitor ECG and keep potassium and magnesium normal; watch for palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Nilotinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib prolongs QTc, and vilanterol, a beta-agonist, may add cardiovascular effects. Systemic exposure from inhalation is low, so the risk is modest.
How serious is the interaction between Nilotinib and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium normal; watch for palpitations.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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