Drug interactions
Nilotinib + Vincristine liposomal
Severity: Moderate
Nilotinib and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and CYP3A4 and may raise vincristine exposure. This could increase neurotoxicity, including peripheral neuropathy and constipation.
What this interaction means in plain words
Nilotinib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein and CYP3A4 inhibition by nilotinib reduces vincristine clearance.
What to do
Monitor for neurotoxicity and constipation and consider reducing the vincristine dose if symptoms develop. Counsel patients to report numbness, weakness or abdominal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Vincristine liposomal?
MediHelp rates the interaction as moderate. Nilotinib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and CYP3A4 and may raise vincristine exposure. This could increase neurotoxicity, including peripheral neuropathy and constipation.
How serious is the interaction between Nilotinib and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity and constipation and consider reducing the vincristine dose if symptoms develop. Counsel patients to report numbness, weakness or abdominal symptoms.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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