Drug interactions
Nilotinib + Zolpidem
Severity: Minor
Nilotinib and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a weak to moderate CYP3A4 inhibitor and could raise zolpidem exposure, increasing sedation. Nilotinib also prolongs the QT interval, but this does not directly involve zolpidem.
What this interaction means in plain words
Nilotinib and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nilotinib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by nilotinib may reduce zolpidem clearance.
What to do
Start with the lowest zolpidem dose and monitor for excessive sedation or next-day impairment, reducing the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zolpidem
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Zolpidem?
MediHelp rates the interaction as minor. Nilotinib and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib is a weak to moderate CYP3A4 inhibitor and could raise zolpidem exposure, increasing sedation. Nilotinib also prolongs the QT interval, but this does not directly involve zolpidem.
How serious is the interaction between Nilotinib and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest zolpidem dose and monitor for excessive sedation or next-day impairment, reducing the dose if needed.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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