Drug interactions
Nirmatrelvir + Raltegravir
Severity: Minor
Nirmatrelvir and Raltegravir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir is given with ritonavir, which can induce UGT1A1 and modestly lower raltegravir exposure. With a short course the effect is expected to be limited.
What this interaction means in plain words
Nirmatrelvir and Raltegravir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nirmatrelvir belongs to Anti Virals; Raltegravir belongs to Anti Virals.
Why it happens
Ritonavir-mediated induction of UGT1A1 increases glucuronidation of raltegravir.
What to do
No dose change is generally required for a five-day course. Monitor virologic control if HIV viral suppression is tenuous.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicated
- Aluminum hydroxide / magnesium carbonate + Raltegravir Major
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Major
- Aluminum hydroxide + Raltegravir Major
- Atidarsagene autotemcel + Raltegravir Major
- Betibeglogene autotemcel + Raltegravir Major
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Nirmatrelvir with Raltegravir?
MediHelp rates the interaction as minor. Nirmatrelvir and Raltegravir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nirmatrelvir is given with ritonavir, which can induce UGT1A1 and modestly lower raltegravir exposure. With a short course the effect is expected to be limited.
How serious is the interaction between Nirmatrelvir and Raltegravir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required for a five-day course. Monitor virologic control if HIV viral suppression is tenuous.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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