Drug interactions
Nirmatrelvir / ritonavir + Raltegravir
Severity: Minor
Nirmatrelvir / ritonavir and Raltegravir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir can induce UGT1A1 and modestly lower raltegravir concentrations. The effect during a short course is expected to be small.
What this interaction means in plain words
Nirmatrelvir / ritonavir and Raltegravir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ritonavir induces UGT1A1, raising glucuronidation clearance of raltegravir.
What to do
Continue raltegravir at the usual dose and monitor HIV viral load if suppression is a concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicated
- Aluminum hydroxide / magnesium carbonate + Raltegravir Major
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Major
- Aluminum hydroxide + Raltegravir Major
- Atidarsagene autotemcel + Raltegravir Major
- Betibeglogene autotemcel + Raltegravir Major
Frequently asked questions
Can I take Nirmatrelvir / ritonavir with Raltegravir?
MediHelp rates the interaction as minor. Nirmatrelvir / ritonavir and Raltegravir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir can induce UGT1A1 and modestly lower raltegravir concentrations. The effect during a short course is expected to be small.
How serious is the interaction between Nirmatrelvir / ritonavir and Raltegravir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue raltegravir at the usual dose and monitor HIV viral load if suppression is a concern.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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