Drug interactions
Nirmatrelvir / ritonavir + Sofosbuvir-velpatasvir
Severity: Minor
Nirmatrelvir / ritonavir and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A and P-gp inhibitor and also affects other enzymes, which could raise exposure to velpatasvir and sofosbuvir. Short courses generally carry limited risk, but exposure changes are possible.
What this interaction means in plain words
Nirmatrelvir / ritonavir and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ritonavir inhibition of CYP3A and P-gp may raise velpatasvir and sofosbuvir exposure.
What to do
Coadministration over the 5-day course is usually acceptable; monitor for antiviral adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Frequently asked questions
Can I take Nirmatrelvir / ritonavir with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Nirmatrelvir / ritonavir and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir is a strong CYP3A and P-gp inhibitor and also affects other enzymes, which could raise exposure to velpatasvir and sofosbuvir. Short courses generally carry limited risk, but exposure changes are possible.
How serious is the interaction between Nirmatrelvir / ritonavir and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration over the 5-day course is usually acceptable; monitor for antiviral adverse effects.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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