Drug interactions
Nitroglycerin rectal + Sacubitril-valsartan
Severity: Moderate
Nitroglycerin rectal and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so concurrent use can cause additive hypotension, dizziness or syncope. This is most relevant when treatment is started or doses are increased. Rectal nitroglycerin is used for anal fissure, with limited systemic absorption but still some vasodilation.
What this interaction means in plain words
Nitroglycerin rectal and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through nitric oxide-mediated venous and arterial relaxation plus angiotensin receptor blockade and neprilysin inhibition.
What to do
Monitor blood pressure and advise patients to rise slowly and report lightheadedness. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nitroglycerin rectal and Sacubitril-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Nitroglycerin rectal with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so concurrent use can cause additive hypotension, dizziness or syncope. This is most relevant when treatment is started or doses are increased. Rectal nitroglycerin is used for anal fissure, with limited systemic absorption but still some vasodilation.
How serious is the interaction between Nitroglycerin rectal and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and advise patients to rise slowly and report lightheadedness. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
