Drug interactions
Nitroglycerin rectal + Spironolactone
Severity: Moderate
Nitroglycerin rectal and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a vasodilator and spironolactone lowers blood pressure, so together they can cause additive hypotension. Dizziness or fainting may occur, especially on standing.
What this interaction means in plain words
Nitroglycerin rectal and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from nitrate-induced vasodilation and diuretic-related volume reduction.
What to do
Monitor blood pressure, including standing readings, when starting or adjusting the nitrate. Advise patients to rise slowly and reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Nitroglycerin rectal with Spironolactone?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a vasodilator and spironolactone lowers blood pressure, so together they can cause additive hypotension. Dizziness or fainting may occur, especially on standing.
How serious is the interaction between Nitroglycerin rectal and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or adjusting the nitrate. Advise patients to rise slowly and reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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