Drug interactions
Nitroglycerin rectal + Trandolapril
Severity: Moderate
Nitroglycerin rectal and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates cause venous and arterial vasodilation, and combining them with an ACE inhibitor can produce additive blood pressure reduction. Patients may have dizziness or syncope, especially on standing.
What this interaction means in plain words
Nitroglycerin rectal and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation: nitric oxide-mediated relaxation plus ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Reduce the dose of one agent if hypotension is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Nitroglycerin rectal with Trandolapril?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates cause venous and arterial vasodilation, and combining them with an ACE inhibitor can produce additive blood pressure reduction. Patients may have dizziness or syncope, especially on standing.
How serious is the interaction between Nitroglycerin rectal and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Reduce the dose of one agent if hypotension is troublesome.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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