Drug interactions
Nitroglycerin rectal + Triamterene
Severity: Moderate
Nitroglycerin rectal and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin causes vasodilation, and triamterene may reduce circulating volume, so blood pressure lowering can be additive. This may cause dizziness, syncope, or falls.
What this interaction means in plain words
Nitroglycerin rectal and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from nitrate vasodilation and diuretic volume depletion.
What to do
Monitor blood pressure and counsel patients to rise slowly; adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Nitroglycerin rectal with Triamterene?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin causes vasodilation, and triamterene may reduce circulating volume, so blood pressure lowering can be additive. This may cause dizziness, syncope, or falls.
How serious is the interaction between Nitroglycerin rectal and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients to rise slowly; adjust doses if symptomatic hypotension occurs.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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