Drug interactions
Nitroglycerin rectal + Valsartan
Severity: Moderate
Nitroglycerin rectal and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure through different mechanisms, so combined use can cause additive hypotension. Dizziness, syncope and reduced organ perfusion may occur, particularly in volume-depleted or elderly patients.
What this interaction means in plain words
Nitroglycerin rectal and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory and hypotensive effects (nitrate-mediated venodilation plus angiotensin receptor blockade).
What to do
Monitor blood pressure and orthostatic symptoms, particularly at initiation or dose increases. Counsel patients to rise slowly and reduce doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Nitroglycerin rectal with Valsartan?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure through different mechanisms, so combined use can cause additive hypotension. Dizziness, syncope and reduced organ perfusion may occur, particularly in volume-depleted or elderly patients.
How serious is the interaction between Nitroglycerin rectal and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at initiation or dose increases. Counsel patients to rise slowly and reduce doses if symptomatic hypotension develops.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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