Drug interactions
Noni juice + Sacubitril-valsartan
Severity: Moderate
Noni juice and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Noni juice has a high potassium content, and sacubitril-valsartan reduces potassium excretion through angiotensin receptor blockade. Regular intake could contribute to hyperkalemia, particularly in patients with renal impairment.
What this interaction means in plain words
Noni juice and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium load from the juice combined with reduced renal potassium excretion from reduced aldosterone effect.
What to do
Advise patients with heart failure or kidney disease to avoid regular noni juice consumption. Check serum potassium if intake is ongoing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Noni juice with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Noni juice and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Noni juice has a high potassium content, and sacubitril-valsartan reduces potassium excretion through angiotensin receptor blockade. Regular intake could contribute to hyperkalemia, particularly in patients with renal impairment.
How serious is the interaction between Noni juice and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients with heart failure or kidney disease to avoid regular noni juice consumption. Check serum potassium if intake is ongoing.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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