Drug interactions
Norepinephrine + Rasagiline
Severity: Major
Norepinephrine and Rasagiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the pressor effects of sympathomimetic amines. Although selective MAO-B inhibitors have a lower risk at recommended doses, norepinephrine given with rasagiline may cause an exaggerated rise in blood pressure.
What this interaction means in plain words
Norepinephrine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive adrenergic effects, with reduced catecholamine metabolism from MAO inhibition.
What to do
Use cautiously in critical care, starting at a low dose with continuous blood pressure monitoring and titrating slowly. Consider holding rasagiline if prolonged vasopressor use is anticipated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Norepinephrine and Rasagiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Norepinephrine with Rasagiline?
MediHelp rates the interaction as major. Norepinephrine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate the pressor effects of sympathomimetic amines. Although selective MAO-B inhibitors have a lower risk at recommended doses, norepinephrine given with rasagiline may cause an exaggerated rise in blood pressure.
How serious is the interaction between Norepinephrine and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use cautiously in critical care, starting at a low dose with continuous blood pressure monitoring and titrating slowly. Consider holding rasagiline if prolonged vasopressor use is anticipated.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
