Drug interactions
Norepinephrine + Sacubitril-valsartan
Severity: Moderate
Norepinephrine and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is a vasopressor that directly opposes the hypotensive effect of sacubitril-valsartan, and it can modestly shift potassium into cells. In critically ill patients on this drug, vasopressor requirements may be higher because angiotensin receptor blockade blunts vasoconstrictor tone.
What this interaction means in plain words
Norepinephrine and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-adrenergic vasoconstriction opposes vasodilation from angiotensin receptor blockade, and beta-mediated cellular potassium shifts oppose potassium retention.
What to do
In patients on sacubitril-valsartan requiring vasopressors, monitor blood pressure continuously and consider holding the drug during shock. Check serum potassium and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Norepinephrine with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Norepinephrine and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine is a vasopressor that directly opposes the hypotensive effect of sacubitril-valsartan, and it can modestly shift potassium into cells. In critically ill patients on this drug, vasopressor requirements may be higher because angiotensin receptor blockade blunts vasoconstrictor tone.
How serious is the interaction between Norepinephrine and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients on sacubitril-valsartan requiring vasopressors, monitor blood pressure continuously and consider holding the drug during shock. Check serum potassium and renal function.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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