Drug interactions
Norepinephrine + Salmeterol
Severity: Moderate
Norepinephrine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents stimulate adrenergic receptors, so together they can increase heart rate, provoke arrhythmias and alter blood pressure. Beta-2 stimulation may also lower potassium, adding to arrhythmic risk.
What this interaction means in plain words
Norepinephrine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic receptor stimulation.
What to do
Monitor ECG, blood pressure and potassium during norepinephrine infusion in patients on salmeterol. Treat hypokalemia and arrhythmias promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Norepinephrine with Salmeterol?
MediHelp rates the interaction as moderate. Norepinephrine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents stimulate adrenergic receptors, so together they can increase heart rate, provoke arrhythmias and alter blood pressure. Beta-2 stimulation may also lower potassium, adding to arrhythmic risk.
How serious is the interaction between Norepinephrine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, blood pressure and potassium during norepinephrine infusion in patients on salmeterol. Treat hypokalemia and arrhythmias promptly.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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