Drug interactions
Nortriptyline + Parecoxib
Severity: Minor
Nortriptyline and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib's active metabolite valdecoxib is not a clinically important CYP2D6 inhibitor, so no meaningful rise in nortriptyline levels is expected. Any interaction is likely minimal.
What this interaction means in plain words
Nortriptyline and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak possible CYP2D6 inhibition; no established clinically relevant mechanism.
What to do
No dose adjustment is needed. Monitor for tricyclic adverse effects if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Parecoxib?
MediHelp rates the interaction as minor. Nortriptyline and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib's active metabolite valdecoxib is not a clinically important CYP2D6 inhibitor, so no meaningful rise in nortriptyline levels is expected. Any interaction is likely minimal.
How serious is the interaction between Nortriptyline and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for tricyclic adverse effects if symptoms arise.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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