Drug interactions
Nortriptyline + Phendimetrazine
Severity: Moderate
Nortriptyline and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic whose effects can be altered by tricyclics, which block norepinephrine reuptake and the neuronal uptake of indirect agents. The result may be unpredictable blood pressure and heart rate changes, with increased risk of hypertension and arrhythmia.
What this interaction means in plain words
Nortriptyline and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclic blockade of norepinephrine transporter alters the response to indirect sympathomimetics, with additive adrenergic stimulation.
What to do
Monitor blood pressure and heart rate, and reconsider the anorectic if hypertension or palpitations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Phendimetrazine?
MediHelp rates the interaction as moderate. Nortriptyline and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic whose effects can be altered by tricyclics, which block norepinephrine reuptake and the neuronal uptake of indirect agents. The result may be unpredictable blood pressure and heart rate changes, with increased risk of hypertension and arrhythmia.
How serious is the interaction between Nortriptyline and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and reconsider the anorectic if hypertension or palpitations occur.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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