Drug interactions
Nortriptyline + Pirbuterol
Severity: Moderate
Nortriptyline and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline may potentiate pirbuterol's cardiovascular effects, with risk of tachycardia, blood pressure changes and arrhythmia.
What this interaction means in plain words
Nortriptyline and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics inhibit noradrenaline reuptake and may amplify beta-agonist cardiovascular effects.
What to do
Monitor pulse, blood pressure and rhythm, and use the lowest effective pirbuterol dose. Change bronchodilator if cardiac effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Pirbuterol?
MediHelp rates the interaction as moderate. Nortriptyline and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline may potentiate pirbuterol's cardiovascular effects, with risk of tachycardia, blood pressure changes and arrhythmia.
How serious is the interaction between Nortriptyline and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse, blood pressure and rhythm, and use the lowest effective pirbuterol dose. Change bronchodilator if cardiac effects occur.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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