Drug interactions
Nortriptyline + Procainamide
Severity: Contraindicated
Nortriptyline and Procainamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow cardiac conduction and can prolong the QT interval. Combined use raises the risk of torsades de pointes and conduction block.
What this interaction means in plain words
Nortriptyline and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive sodium channel blockade and QT prolongation.
What to do
Avoid the combination and choose alternatives. If unavoidable, monitor ECG continuously and correct electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Procainamide?
MediHelp rates the interaction as contraindicated. Nortriptyline and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs slow cardiac conduction and can prolong the QT interval. Combined use raises the risk of torsades de pointes and conduction block.
How serious is the interaction between Nortriptyline and Procainamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose alternatives. If unavoidable, monitor ECG continuously and correct electrolytes.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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