Drug interactions
Nortriptyline + Progesterone micronized
Severity: Minor
Nortriptyline and Progesterone micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sex hormones, mainly estrogens, have been reported to alter tricyclic antidepressant exposure and effect, but data for micronized progesterone are sparse. A clinically meaningful change in nortriptyline response or tolerability is possible but unproven.
What this interaction means in plain words
Nortriptyline and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible hormonal influence on hepatic metabolism of the tricyclic; mechanism not firmly established.
What to do
No routine adjustment is needed; if the patient shows loss of antidepressant effect or anticholinergic or cardiac adverse effects after starting progesterone, consider checking nortriptyline serum levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Progesterone micronized?
MediHelp rates the interaction as minor. Nortriptyline and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sex hormones, mainly estrogens, have been reported to alter tricyclic antidepressant exposure and effect, but data for micronized progesterone are sparse. A clinically meaningful change in nortriptyline response or tolerability is possible but unproven.
How serious is the interaction between Nortriptyline and Progesterone micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; if the patient shows loss of antidepressant effect or anticholinergic or cardiac adverse effects after starting progesterone, consider checking nortriptyline serum levels.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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