Drug interactions
Nortriptyline + Romidepsin
Severity: Moderate
Nortriptyline and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and ECG changes have been seen with romidepsin. Combined use may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances.
What this interaction means in plain words
Nortriptyline and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Check baseline and periodic ECGs and correct potassium and magnesium abnormalities. Consider a non-QT-prolonging antidepressant if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Romidepsin?
MediHelp rates the interaction as moderate. Nortriptyline and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and ECG changes have been seen with romidepsin. Combined use may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances.
How serious is the interaction between Nortriptyline and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs and correct potassium and magnesium abnormalities. Consider a non-QT-prolonging antidepressant if risk factors are present.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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