Drug interactions
Nortriptyline + Thiothixene
Severity: Moderate
Nortriptyline and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and have anticholinergic properties, so together they increase drowsiness and antimuscarinic effects. Nortriptyline may also raise antipsychotic levels via CYP2D6 competition, and both can affect cardiac conduction and lower the seizure threshold.
What this interaction means in plain words
Nortriptyline and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, anticholinergic and cardiac effects, with possible CYP2D6-mediated metabolic competition.
What to do
Monitor sedation, anticholinergic effects, ECG and seizure risk. Adjust doses of either drug as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Thiothixene?
MediHelp rates the interaction as moderate. Nortriptyline and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and have anticholinergic properties, so together they increase drowsiness and antimuscarinic effects. Nortriptyline may also raise antipsychotic levels via CYP2D6 competition, and both can affect cardiac conduction and lower the seizure threshold.
How serious is the interaction between Nortriptyline and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, anticholinergic effects, ECG and seizure risk. Adjust doses of either drug as needed.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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