Drug interactions
Nortriptyline + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Nortriptyline and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics can potentiate the cardiovascular effects of vilanterol, a long-acting beta agonist, and both can affect the QT interval. This may cause tachycardia, hypertension or arrhythmia. Umeclidinium adds anticholinergic load.
What this interaction means in plain words
Nortriptyline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic and QT effects, with tricyclic potentiation of beta-agonist cardiovascular response.
What to do
Monitor heart rate, blood pressure and ECG in patients with cardiac disease, and watch for urinary retention and dry mouth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Nortriptyline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclics can potentiate the cardiovascular effects of vilanterol, a long-acting beta agonist, and both can affect the QT interval. This may cause tachycardia, hypertension or arrhythmia. Umeclidinium adds anticholinergic load.
How serious is the interaction between Nortriptyline and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with cardiac disease, and watch for urinary retention and dry mouth.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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