Drug interactions
Nortriptyline + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Nortriptyline and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of the beta agonist vilanterol, and both may affect QT interval. This may lead to tachycardia, blood pressure rise or arrhythmia.
What this interaction means in plain words
Nortriptyline and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation and QT effects, with tricyclic potentiation of beta-agonist response.
What to do
Monitor heart rate, blood pressure and ECG in patients with cardiac risk, and reassess inhaler therapy if palpitations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Nortriptyline and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of the beta agonist vilanterol, and both may affect QT interval. This may lead to tachycardia, blood pressure rise or arrhythmia.
How serious is the interaction between Nortriptyline and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with cardiac risk, and reassess inhaler therapy if palpitations occur.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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