Drug interactions
Octreotide + Pasireotide
Severity: Moderate
Octreotide and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are somatostatin analogs that can prolong the QTc interval and cause bradycardia. Combining them increases the risk of arrhythmia and offers little rationale because they act on the same receptors.
What this interaction means in plain words
Octreotide and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Additive QT prolongation and bradycardia from somatostatin receptor agonism.
What to do
Avoid routine combination unless specifically intended, such as a transition between agents. If used together, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Octreotide with Pasireotide?
MediHelp rates the interaction as moderate. Octreotide and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are somatostatin analogs that can prolong the QTc interval and cause bradycardia. Combining them increases the risk of arrhythmia and offers little rationale because they act on the same receptors.
How serious is the interaction between Octreotide and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination unless specifically intended, such as a transition between agents. If used together, monitor ECG and correct potassium and magnesium.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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