Drug interactions
Octreotide + Pazopanib
Severity: Moderate
Octreotide and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is associated with QT prolongation and torsades de pointes, and octreotide can cause bradycardia and QT changes. Combined use may increase arrhythmia risk.
What this interaction means in plain words
Octreotide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform baseline and periodic ECG monitoring and keep potassium and magnesium within normal range. Reassess therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Octreotide with Pazopanib?
MediHelp rates the interaction as moderate. Octreotide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is associated with QT prolongation and torsades de pointes, and octreotide can cause bradycardia and QT changes. Combined use may increase arrhythmia risk.
How serious is the interaction between Octreotide and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform baseline and periodic ECG monitoring and keep potassium and magnesium within normal range. Reassess therapy if QTc becomes markedly prolonged.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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