Drug interactions
Octreotide + Promethazine
Severity: Moderate
Octreotide and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and promethazine may add to QT effects. The overall risk is modest but may matter in patients with cardiac disease or electrolyte disorders.
What this interaction means in plain words
Octreotide and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization, with octreotide-related bradycardia.
What to do
Monitor ECG and heart rate in at-risk patients and keep potassium and magnesium in range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Promethazine?
MediHelp rates the interaction as moderate. Octreotide and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and promethazine may add to QT effects. The overall risk is modest but may matter in patients with cardiac disease or electrolyte disorders.
How serious is the interaction between Octreotide and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate in at-risk patients and keep potassium and magnesium in range.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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