Drug interactions
Octreotide + Quinine
Severity: Moderate
Octreotide and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and quinine adds to the QT effect. The combination may increase arrhythmia risk in vulnerable patients.
What this interaction means in plain words
Octreotide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia further predisposing to torsades de pointes.
What to do
Check ECG and electrolytes at baseline and during co-therapy, especially with bradycardia or cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Quinine?
MediHelp rates the interaction as moderate. Octreotide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and quinine adds to the QT effect. The combination may increase arrhythmia risk in vulnerable patients.
How serious is the interaction between Octreotide and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during co-therapy, especially with bradycardia or cardiac disease.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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