Drug interactions
Ofatumumab sc + Sunitinib
Severity: Moderate
Ofatumumab sc and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair immune or hematologic function, so combined use may raise infection risk. Ofatumumab depletes B cells while sunitinib can cause neutropenia and other cytopenias.
What this interaction means in plain words
Ofatumumab sc and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppressive and myelosuppressive effects (pharmacodynamic).
What to do
Monitor for signs of infection and check blood counts periodically. Ensure screening such as hepatitis B before ofatumumab is completed and consider timing of prior immunosuppressive therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Ofatumumab sc with Sunitinib?
MediHelp rates the interaction as moderate. Ofatumumab sc and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair immune or hematologic function, so combined use may raise infection risk. Ofatumumab depletes B cells while sunitinib can cause neutropenia and other cytopenias.
How serious is the interaction between Ofatumumab sc and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts periodically. Ensure screening such as hepatitis B before ofatumumab is completed and consider timing of prior immunosuppressive therapy.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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