Drug interactions
Ofatumumab sc + Tocilizumab
Severity: Moderate
Ofatumumab sc and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and tocilizumab blocks IL-6 signalling, so together they can add to the risk of serious infection. B-cell depletion persists after the last ofatumumab dose.
What this interaction means in plain words
Ofatumumab sc and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression via B-cell depletion and IL-6 receptor blockade.
What to do
Monitor for infection and consider baseline and periodic immunoglobulin and lymphocyte assessment. Account for the prolonged effect of ofatumumab when switching.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Ofatumumab sc with Tocilizumab?
MediHelp rates the interaction as moderate. Ofatumumab sc and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and tocilizumab blocks IL-6 signalling, so together they can add to the risk of serious infection. B-cell depletion persists after the last ofatumumab dose.
How serious is the interaction between Ofatumumab sc and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and consider baseline and periodic immunoglobulin and lymphocyte assessment. Account for the prolonged effect of ofatumumab when switching.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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